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Elovl4tm1Sie
Targeted Allele Detail
Nomenclature
Symbol: Elovl4tm1Sie
Name: elongation of very long chain fatty acids (FEN1/Elo2, SUR4/Elo3, yeast)-like 4; targeted mutation 1, Paul A Sieving
MGI ID: MGI:3664793
Gene: Elovl4  Location: Chr9:83778692-83806277 bp, - strand  Genetic Position: Chr9, 45.6 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112264
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 62 bp deletion in exon2 and a splice acceptor, IRES, lacZ, and PGK-neo cassette were inserted via homologous recombination. (J:112264)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Elovl4 Mutation:  17 strains or lines available
References
Original:  J:112264 Raz-Prag D, et al., Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3603-11
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/07/2019
MGI 6.14
The Jackson Laboratory