Elovl4^tm1Sie
Targeted Allele Detail

Summary

• Symbol: Elovl4^tm1Sie
• Name: ELOVL fatty acid elongase 4; targeted mutation 1, Paul A Sieving
• MGI ID: MGI:3664793
• Gene: Elovl4 Location: Chr9:83660745-83688330 bp, - strand Genetic Position: Chr9, 45.6 cM
• Alliance: Elovl4^tm1Sie page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:112264
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Null/knockout, Reporter)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A 62 bp deletion in exon2 and a splice acceptor, IRES, lacZ, and PGK-neo cassette were inserted via homologous recombination. (J:112264)

Disease models

Expression

In Structures Affected by this Mutation:

3 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Elovl4 Mutation: 35 strains or lines available

References

• Original: J:112264 Raz-Prag D, et al., Haploinsufficiency is not the key mechanism of pathogenesis in a heterozygous Elovl4 knockout mouse model of STGD3 disease. Invest Ophthalmol Vis Sci. 2006 Aug;47(8):3603-11
• All: 2 reference(s)