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Cd8atm2Kio
Targeted Allele Detail
Nomenclature
Symbol: Cd8atm2Kio
Name: CD8 antigen, alpha chain; targeted mutation 2, Dimitris Kioussis
MGI ID: MGI:3664645
Synonyms: CIIIdelta1,2, delta1
Gene: Cd8a  Location: Chr6:71373427-71379173 bp, + strand  Genetic Position: Chr6, 32.14 cM, cytoband C
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110530
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance gene replaced an 8 kb fragment containing the cluster CIII DNaseI hypersensitivity sites CIII-1 and CIII-2. (J:110530)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cd8a Mutation:  19 strains or lines available
References
Original:  J:110530 Hostert A, et al., Hierarchical interactions of control elements determine CD8alpha gene expression in subsets of thymocytes and peripheral T cells. Immunity. 1998 Oct;9(4):497-508
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory