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Gt(ROSA)26Sortm1(CTNNB1)Nerl
Targeted Allele Detail
Nomenclature
Symbol: Gt(ROSA)26Sortm1(CTNNB1)Nerl
Name: gene trap ROSA 26, Philippe Soriano; targeted mutation 1 Claus Nerlov
MGI ID: MGI:3664628
Gene: Gt(ROSA)26Sor  Location: Chr6:113067428-113077244 bp, - strand  Genetic Position: Chr6, 52.73 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112660
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Gt(ROSA)26Sortm1(CTNNB1)Nerl expresses 1 gene
 
Mutation detailsA cDNA encoding a Myc-tagged stable form of human CTNNB1 was inserted into the locus downstream of a floxed neo cassette using RecE-RecT recombination. Cre mediated removal of the neo allows expression of the inserted gene. (J:112660)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gt(ROSA)26Sor Mutation:  512 strains or lines available
References
Original:  J:112660 Kirstetter P, et al., Activation of the canonical Wnt pathway leads to loss of hematopoietic stem cell repopulation and multilineage differentiation block. Nat Immunol. 2006 Oct;7(10):1048-56
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/18/2020
MGI 6.14
The Jackson Laboratory