Tmem176b^tm1Tto
Targeted Allele Detail

Summary

• Symbol: Tmem176b^tm1Tto
• Name: transmembrane protein 176B; targeted mutation 1, Takeshi Tokuhisa
• MGI ID: MGI:3664609
• Synonyms: Clast1-KO
• Gene: Tmem176b Location: Chr6:48810745-48818363 bp, - strand Genetic Position: Chr6, 23.75 cM
• Alliance: Tmem176b^tm1Tto page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111587
• Parent Cell Line: R1 (ES Cell)
• Strain of Origin: (129X1/SvJ x 129S1/Sv)F1-Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: Exon 2 with the ATG start codon was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis confirmed the absence of mRNA in the lungs. (J:111587)

Expression

In Mice Carrying this Mutation:	5 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Tmem176b Mutation: 20 strains or lines available

References

• Original: J:111587 Maeda Y, et al., Role of Clast1 in development of cerebellar granule cells. Brain Res. 2006 Aug 9;1104(1):18-26
• All: 1 reference(s)