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Tmem176btm1Tto
Targeted Allele Detail
Nomenclature
Symbol: Tmem176btm1Tto
Name: transmembrane protein 176B; targeted mutation 1, Takeshi Tokuhisa
MGI ID: MGI:3664609
Synonyms: Clast1-KO
Gene: Tmem176b  Location: Chr6:48833818-48841496 bp, - strand  Genetic Position: Chr6, 23.75 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111587
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExon 2 with the ATG start codon was replaced with a neomycin resistance cassette via homologous recombination. Northern blot analysis confirmed the absence of mRNA in the lungs. (J:111587)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmem176b Mutation:  10 strains or lines available
References
Original:  J:111587 Maeda Y, et al., Role of Clast1 in development of cerebellar granule cells. Brain Res. 2006 Aug 9;1104(1):18-26
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory