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Targeted Allele Detail
Symbol: Ciitatm1.1Dim
Name: class II transactivator; targeted mutation 1.1, Diane Mathis
MGI ID: MGI:3664552
Synonyms: CIITA0
Gene: Ciita  Location: Chr16:10480059-10528418 bp, + strand  Genetic Position: Chr16, 5.65 cM, cytoband B1
Germline Transmission:  Earliest citation of germline transmission: J:51885
Parent Cell Line:  D3 (ES Cell)
Strain of Origin:  129S2/SvPas
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsA single loxP site was introduced 5' to exon 2 and a loxP-flanked thymidine kinase-neomycin fusion gene was inserted 3' to exon 3. Cre-mediated deletion of the intervening sequences was accomplished by mating mutant mice to CMV-cre mice, deleting the DNA encoding the major transactivation domain. RT-PCR analysis on spleen and thymus RNA indicated that no detectable transcript is expressed from this allele. (J:51885)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Ciita Mutation:  8 strains or lines available
Original:  J:51885 Williams GS, et al., Mice lacking the transcription factor CIITA--a second look. Int Immunol. 1998 Dec;10(12):1957-67
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory