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Targeted Allele Detail
Symbol: Chst5tm1Knsh
Name: carbohydrate (N-acetylglucosamine 6-O) sulfotransferase 5; targeted mutation 1, Kohji Nishida
MGI ID: MGI:3664471
Gene: Chst5  Location: Chr8:111889135-111910199 bp, - strand  Genetic Position: Chr8, 58.11 cM, cytoband E1
Corneas of wild type, Chst5tm1Knsh/Chst5+ and Chst5tm1Knsh/Chst5tm1Knsh mice

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:112899
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsExon 2 was replaced with a neomycin-resistance gene. RT-PCR confirmed the absence of transcript in the whole eyes of null mice. (J:112899)
View phenotypes for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Chst5 Mutation:  54 strains or lines available
Original:  J:112899 Hayashida Y, et al., Matrix morphogenesis in cornea is mediated by the modification of keratan sulfate by GlcNAc 6-O-sulfotransferase. Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13333-8
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.06
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