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Cyldtm1Scs
Targeted Allele Detail
Nomenclature
Symbol: Cyldtm1Scs
Name: CYLD lysine 63 deubiquitinase; targeted mutation 1, Shao-Cong Sun
MGI ID: MGI:3664438
Synonyms: Cyld-
Gene: Cyld  Location: Chr8:88697047-88751945 bp, + strand  Genetic Position: Chr8, 43.51 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112392
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutation:    Insertion
 
Mutation detailsA neomycin resistance cassette was inserted into exon 1. RT-PCR failed to detect transcript in mutant spleen or liver samples. Protein was absent in immunoblot analysis. (J:112392)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cyld Mutation:  21 strains or lines available
References
Original:  J:112392 Reiley WW, et al., Regulation of T cell development by the deubiquitinating enzyme CYLD. Nat Immunol. 2006 Apr;7(4):411-7
All:  13 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/19/2017
MGI 6.10
The Jackson Laboratory