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Targeted Allele Detail
Symbol: Irf4tm1Rdf
Name: interferon regulatory factor 4; targeted mutation 1, Riccardo Dalla-Favera
MGI ID: MGI:3664434
Synonyms: Irf4fl
Gene: Irf4  Location: Chr13:30749233-30766981 bp, + strand  Genetic Position: Chr13, 13.28 cM, cytoband A3.3
Germline Transmission:  Earliest citation of germline transmission: J:112643
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA targeting construct was designed to insert an frt-EGFP-loxP sequence upstream of exon 1 and a loxP-PGK-frt downstream of exon 2 such that cre mediated excision would remove the exons while allowing EGFP expression and, alternatively, FLP-mediated excision would remove both the exons and the EGFP. (J:112643)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Irf4 Mutation:  16 strains or lines available
Original:  J:112643 Klein U, et al., Transcription factor IRF4 controls plasma cell differentiation and class-switch recombination. Nat Immunol. 2006 Jul;7(7):773-82
All:  83 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory