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Targeted Allele Detail
Symbol: Myh6tm2Jse
Name: myosin, heavy polypeptide 6, cardiac muscle, alpha; targeted mutation 2, Jonathan G Seidman
MGI ID: MGI:3664197
Synonyms: R453C, RC
Gene: Myh6  Location: Chr14:54941921-54966927 bp, - strand  Genetic Position: Chr14, 28.01 cM
Germline Transmission:  Earliest citation of germline transmission: J:95600
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
Mutation detailsA targeted mutation causes an R453C mutation in the protein product. A detailed description of this allele has not yet been published. (J:95600)
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Structures Affected by this Mutation: 5 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh6 Mutation:  28 strains or lines available
Original:  J:95600 Palmer BM, et al., Differential cross-bridge kinetics of FHC myosin mutations R403Q and R453C in heterozygous mouse myocardium. Am J Physiol Heart Circ Physiol. 2004 Jul;287(1):H91-9
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory