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Map3k7tm1Aki
Targeted Allele Detail
Nomenclature
Symbol: Map3k7tm1Aki
Name: mitogen-activated protein kinase kinase kinase 7; targeted mutation 1, Shizuo Akira
MGI ID: MGI:3664193
Synonyms: Map3k7flox, TAK1FL, TAK1fx
Gene: Map3k7  Location: Chr4:31964097-32023467 bp, + strand  Genetic Position: Chr4, 13.91 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112597
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to flank exon 2 with loxP sites. This exon encodes part of the kinase domain, including the ATP-binding site. (J:112597)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 10 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Map3k7 Mutation:  34 strains or lines available
Notes
Phenotypic Similarity to Human Syndrome: Inflammatory Bowel Disease J: 238318.
References
Original:  J:112597 Sato S, et al., Essential function for the kinase TAK1 in innate and adaptive immune responses. Nat Immunol. 2005 Nov;6(11):1087-95
All:  48 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory