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Atp2b2jog
Spontaneous Allele Detail
Summary
Symbol: Atp2b2jog
Name: ATPase, Ca++ transporting, plasma membrane 2; joggle
MGI ID: MGI:3664103
Gene: Atp2b2  Location: Chr6:113720792-114019574 bp, - strand  Genetic Position: Chr6, 52.85 cM
Alliance: Atp2b2jog page
Mutation
origin
Strain of Origin:  DSO
Mutation
description
Allele Type:    Spontaneous
Mutation:    Transposon insertion
 
Mutation detailsAn intracisternal A particle (IAP) was found to have inserted at the downstream donor splice site of exon 1. Primary transcripts are prematurely terminated and a chimeric mRNA including fused IAP sequence is produced. Expression of full length mRNA is reduced to about 5% of normal. Expression of full length and chimeric mRNA is reduced to about 60% relative to controls. (J:132712)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Atp2b2 Mutation:  54 strains or lines available
References
Original:  J:111625 Chen Z, et al., A novel mutant mouse, joggle, with inherited ataxia. Exp Anim. 2006 Jul;55(4):411-4
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
11/22/2022
MGI 6.22
The Jackson Laboratory