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Nebtm1(cre)Chen
Targeted Allele Detail
Nomenclature
Symbol: Nebtm1(cre)Chen
Name: nebulin; targeted mutation 1, Ju Chen
MGI ID: MGI:3664092
Synonyms: nebulin-
Gene: Neb  Location: Chr2:52136640-52338798 bp, - strand  Genetic Position: Chr2, 29.98 cM
Nebtm1(cre)Chen/Nebtm1(cre)Chen exhibit decreased postnatal weight and die at postnatal day 8-11

Show the 3 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111470
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout, Recombinase)
Mutation:    Insertion
    Exon 1 was replaced with a cre-neo cassette. Protein was not detected by Western blot analysis. (J:111470)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Neb     Summary of all recombinase alleles driven by Neb.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Neb Mutation:  5 strains or lines available
References
Original:  J:111470 Bang ML, et al., Nebulin-deficient mice exhibit shorter thin filament lengths and reduced contractile function in skeletal muscle. J Cell Biol. 2006 Jun 19;173(6):905-16
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/11/2020
MGI 6.14
The Jackson Laboratory