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Gipc1tm1Mvc
Targeted Allele Detail
Nomenclature
Symbol: Gipc1tm1Mvc
Name: GIPC PDZ domain containing family, member 1; targeted mutation 1, Moses V Chao
MGI ID: MGI:3663921
Synonyms: Gipc1-, synectin-null
Gene: Gipc1  Location: Chr8:83652677-83664694 bp, + strand  Genetic Position: Chr8, 40.22 cM, cytoband C3
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111724
Parent Cell Line:  E14 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 2-4, which encode the entire N-terminal, PDZ and a part of the C-terminal domain, with a neomycin resistance gene. Expression was not detected by Western blot of mutant brain lysates. (J:111724)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gipc1 Mutation:  37 strains or lines available
References
Original:  J:111724 Yano H, et al., BDNF-mediated neurotransmission relies upon a myosin VI motor complex. Nat Neurosci. 2006 Aug;9(8):1009-18
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory