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Bst1tm1Thir
Targeted Allele Detail
Nomenclature
Symbol: Bst1tm1Thir
Name: bone marrow stromal cell antigen 1; targeted mutation 1, Toshio Hirano
MGI ID: MGI:3663800
Synonyms: BST-1-
Gene: Bst1  Location: Chr5:43818880-43843468 bp, + strand  Genetic Position: Chr5, 23.84 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111424
Parent Cell Line:  E14.1TG3B1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA vector was designed to replace sequence encoding part of exon 1, all of exon 2 and part of exon 3 with a neomycin resistnce cassette in opposite transcriptional orientation. RT-PCR confirmed absence of transcript in mutant bone marrow, spleen and thymus. (J:111424)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Bst1 Mutation:  14 strains or lines available
References
Original:  J:111424 Itoh M, et al., Deletion of bone marrow stromal cell antigen-1 (CD157) gene impaired systemic thymus independent-2 antigen-induced IgG3 and mucosal TD antigen-elicited IgA responses. J Immunol. 1998 Oct 15;161(8):3974-83
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory