Htt^tm4Szi
Targeted Allele Detail

Summary

• Symbol: Htt^tm4Szi
• Name: huntingtin; targeted mutation 4, Scott Zeitlin
• MGI ID: MGI:3663763
• Synonyms: Hdh^stop
• Gene: Htt Location: Chr5:34919084-35069878 bp, + strand Genetic Position: Chr5, 17.92 cM
• Alliance: Htt^tm4Szi page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111323
• Parent Cell Line: W9.5/W95 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutation: Disruption caused by insertion of vector
• Mutation details: A vector containing a neostop cassette was designed to insert into intron 1 near the 5' splice donor site. RT-PCR failed to detect transcript from mutants. (J:111323)

Expression

In Structures Affected by this Mutation:

1 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Htt Mutation: 179 strains or lines available

References

• Original: J:111323 Dragatsis I, et al., A method for the generation of conditional gene repair mutations in mice. Nucleic Acids Res. 2001 Feb 1;29(3):E10
• All: 1 reference(s)