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Targeted Allele Detail
Symbol: Ifih1tm1.1Cln
Name: interferon induced with helicase C domain 1; targeted mutation 1.1, Marco Colonna
MGI ID: MGI:3663677
Synonyms: Mda-5-, MDA5
Gene: Ifih1  Location: Chr2:62595798-62646255 bp, - strand  Genetic Position: Chr2, 35.85 cM, cytoband C3
Germline Transmission:  Earliest citation of germline transmission: J:110201
Parent Cell Line:  SCC10 (ES Cell)
Strain of Origin:  129X1/SvJ
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exon 1 and 400 bp of upstream sequence with a floxed MC1-neo cassette. Cre mediated excision removed the MC1-neo, leaving a single loxP site. (J:110201)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Ifih1 Mutation:  26 strains or lines available
Original:  J:110201 Gitlin L, et al., Essential role of mda-5 in type I IFN responses to polyriboinosinic:polyribocytidylic acid and encephalomyocarditis picornavirus. Proc Natl Acad Sci U S A. 2006 May 30;103(22):8459-64
All:  47 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.16
The Jackson Laboratory