About   Help   FAQ
Sp4tm3Krc
Targeted Allele Detail
Nomenclature
Symbol: Sp4tm3Krc
Name: trans-acting transcription factor 4; targeted mutation 3, Kenneth R Chien
MGI ID: MGI:3663671
Synonyms: Sp4-
Gene: Sp4  Location: Chr12:118234933-118301440 bp, - strand  Genetic Position: Chr12, 63.48 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110135
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Hypomorph)
Mutation:    Insertion
 
Mutation detailsA targeting vector was designed to insert a floxed lacZ into intron 1. The rat coding sequence with a mouse 3'UTR was fused in frame to exon 2 of the locus. This allele is a hypomorph. (J:110135)
Phenotypes
Loading...
View phenotypes for all genotypes (concatenated display).
Disease models
Loading...
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Sp4 Mutation:  15 strains or lines available
References
Original:  J:110135 Zhou X, et al., Reduced expression of the Sp4 gene in mice causes deficits in sensorimotor gating and memory associated with hippocampal vacuolization. Mol Psychiatry. 2005 Apr;10(4):393-406
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
09/27/2016
MGI 6.05
The Jackson Laboratory