Igh^tm10Cgn
Targeted Allele Detail

Summary

• Symbol: Igh^tm10Cgn
• Name: immunoglobulin heavy chain complex; targeted mutation 10, University of Cologne
• MGI ID: MGI:3663519
• Synonyms: VDJPE
• Gene: Igh Location: Chr12:113222388-115973574 bp, - strand Genetic Position: Chr12, Syntenic

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111654
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Inserted expressed sequence)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to encode an antibody specific for the fluorescent protein phycoerythrin. The vector was flanked by loxP sites in opposite orientations, allowing inversion upon expression of cre recombinase. (J:111654)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Igh Mutation: 47 strains or lines available

References

• Original: J:111654 Maruyama M, et al., Memory B-cell persistence is independent of persisting immunizing antigen. Nature. 2000 Oct 5;407(6804):636-42
• All: 3 reference(s)