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Blmtm4Ches
Targeted Allele Detail
Nomenclature
Symbol: Blmtm4Ches
Name: Bloom syndrome, RecQ like helicase; targeted mutation 4, Nicholas Chester
MGI ID: MGI:3663359
Synonyms: Blmflox
Gene: Blm  Location: Chr7:80454993-80535148 bp, - strand  Genetic Position: Chr7, 45.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:112115
Parent Cell Line:  TC1/TC-1 (ES Cell)
Strain of Origin:  129S6/SvEvTac
Mutation
description
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
 
Mutation detailsA floxed PGK-neomycin resistance gene was inserted into intron 8 and an additional loxP site was placed in intron 7, 75 bp from the start of exon 8. Transient cre expression removed the PGK-neo sequence from correctly targeted ES cells, leaving loxP sites flanking exon 8. (J:112115)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 1 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blm Mutation:  72 strains or lines available
References
Original:  J:112115 Chester N, et al., Mutation of the murine Bloom's syndrome gene produces global genome destabilization. Mol Cell Biol. 2006 Sep;26(17):6713-26
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
02/04/2020
MGI 6.14
The Jackson Laboratory