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Targeted Allele Detail
Symbol: Il12btm2Lky
Name: interleukin 12b; targeted mutation 2, Richard M Locksley
MGI ID: MGI:3663352
Synonyms: get40, Il-12/p40 g
Gene: Il12b  Location: Chr11:44400063-44414033 bp, + strand  Genetic Position: Chr11, 25.94 cM, cytoband A5-B2
Germline Transmission:  Earliest citation of germline transmission: J:112745
Parent Cell Line:  PC3 (ES Cell)
Strain of Origin:  129S4/SvJae-Tg(Prm-cre)70Og
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA targeting vector was designed to insert an internal ribosomal entry site-enhanced green fluorescent protein (EGFP; Clontech) sequence (followed by a bovine growth hormone poly(A) signal and a loxP-flanked neomycin resistance cassette) downstream of the stop codon in exon 8 of the endogenous gene. (J:112745)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Il12b Mutation:  18 strains or lines available
Original:  J:112745 Reinhardt RL, et al., Visualization of IL-12/23p40 in vivo reveals immunostimulatory dendritic cell migrants that promote Th1 differentiation. J Immunol. 2006 Aug 1;177(3):1618-27
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
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