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Hsh2dtm1Viss
Targeted Allele Detail
Nomenclature
Symbol: Hsh2dtm1Viss
Name: hematopoietic SH2 domain containing; targeted mutation 1, Virginia Smith Shapiro
MGI ID: MGI:3662663
Synonyms: ALX KO
Gene: Hsh2d  Location: Chr8:72189668-72200958 bp, + strand  Genetic Position: Chr8, 34.87 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111408
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resistance cassette replaced exons 2 and 3. These exons encoded the ATG and the SH2 domain FLVR motif. Western blot failed to detect protein in mutants. (J:111408)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hsh2d Mutation:  44 strains or lines available
References
Original:  J:111408 Perchonock CE, et al., Negative regulation of interleukin-2 and p38 mitogen-activated protein kinase during T-cell activation by the adaptor ALX. Mol Cell Biol. 2006 Aug;26(16):6005-15
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
07/19/2016
MGI 6.04
The Jackson Laboratory