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Arf6tm1Yaka
Targeted Allele Detail
Nomenclature
Symbol: Arf6tm1Yaka
Name: ADP-ribosylation factor 6; targeted mutation 1, Yasunori Kanaho
MGI ID: MGI:3662650
Synonyms: Arf6-
Gene: Arf6  Location: Chr12:69372150-69373783 bp, + strand  Genetic Position: Chr12, 28.81 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111404
Parent Cell Line:  E14K (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA vector was designed to replace a fragment encompassing the ATG with a neomycin resistance cassette. Western blot failed to detect protein in mutant MEFs. (J:111404)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 25 assay results
In Structures Affected by this Mutation: 3 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Arf6 Mutation:  7 strains or lines available
References
Original:  J:111404 Suzuki T, et al., Crucial role of the small GTPase ARF6 in hepatic cord formation during liver development. Mol Cell Biol. 2006 Aug;26(16):6149-56
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/22/2020
MGI 6.16
The Jackson Laboratory