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Gnpnat1tm1Mak
Targeted Allele Detail
Nomenclature
Symbol: Gnpnat1tm1Mak
Name: glucosamine-phosphate N-acetyltransferase 1; targeted mutation 1, Tak Mak
MGI ID: MGI:3662646
Synonyms: Emeg32-
Gene: Gnpnat1  Location: Chr14:45613878-45626444 bp, - strand  Genetic Position: Chr14, 22.92 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111395
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 1 and 2 with a neomycin resistance cassette. Western blot analysis demonstrated absence of protein in mutants. (J:111395)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gnpnat1 Mutation:  27 strains or lines available
References
Original:  J:111395 Boehmelt G, et al., Decreased UDP-GlcNAc levels abrogate proliferation control in EMeg32-deficient cells. EMBO J. 2000 Oct 2;19(19):5092-104
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
05/10/2022
MGI 6.19
The Jackson Laboratory