Hprt1^{tm4(ACTB-GFP)Unc}
Targeted Allele Detail

Summary

• Symbol: Hprt1^{tm4(ACTB-GFP)Unc}
• Name: hypoxanthine phosphoribosyltransferase 1; targeted mutation 4, University of North Carolina
• MGI ID: MGI:3662642
• Synonyms: Hprt^tm4Unc, Xp^II-GFPn-II
• Gene: Hprt1 Location: ChrX:52077014-52110536 bp, + strand Genetic Position: ChrX, 29.31 cM, cytoband A6
• Alliance: Hprt1^{tm4(ACTB-GFP)Unc} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:111065
• Parent Cell Line: E14TG2a (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Reporter)
• Mutation: Insertion
• Mutation details: A construct containing the human beta actin promoter adjoined to a GFPn and flanked by double copies of the hypersensitive site 4 (cHS4) from the chicken beta-globin promoter was inserted into the locus. (J:111065)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Hprt1 Mutation: 1280 strains or lines available

References

• Original: J:111065 Ciavatta D, et al., A DNA insulator prevents repression of a targeted X-linked transgene but not its random or imprinted X inactivation. Proc Natl Acad Sci U S A. 2006 Jun 27;103(26):9958-63
• All: 2 reference(s)