Ret^tm1Kln
Targeted Allele Detail

Summary

• Symbol: Ret^tm1Kln
• Name: ret proto-oncogene; targeted mutation 1, Rudiger Klein
• MGI ID: MGI:3662623
• Synonyms: Ret^C, Ret^flx, Ret^lx
• Gene: Ret Location: Chr6:118128706-118174679 bp, - strand Genetic Position: Chr6, 55.86 cM, cytoband E3-F1
• Alliance: Ret^tm1Kln page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:110955
• Parent Cell Line: Not Specified (ES Cell)
• Strain of Origin: Not Specified

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A targeting vector was designed to insert loxP sites to flank exon 12, which encodes the ATP binding site of the kinase domain. An FRT-flanked cassette was included in the vector upstream of floxed exon 12. The neo was subsequently removed by flp expression. (J:110955)

Disease models

Expression

In Structures Affected by this Mutation:

2 anatomical structure(s)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Ret Mutation: 53 strains or lines available

References

• Original: J:110955 Kramer ER, et al., Cooperation between GDNF/Ret and ephrinA/EphA4 signals for motor-axon pathway selection in the limb. Neuron. 2006 Apr 6;50(1):35-47
• All: 13 reference(s)