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Transgene Detail
Symbol: Tg(Pcp2-cre)1Amc
Name: transgene insertion 1, Andrew P McMahon
MGI ID: MGI:3656031
Synonyms: L7Cre, L7-Cre, L7-deltaAUG Cre
Transgene: Tg(Pcp2-cre)1Amc  Location: unknown  
Strain of Origin:  Black Swiss
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
Mutation detailsThe transgene was generated by placing the L7-deltaAUG promoter enhancer (from the L7-deltaAUG vector in which all upstream ATGs have been mutated) upstream of cre in the pSP-13Cre plasmid. The L7/Pcp2 modified promoter can direct tissue specific expression of genes downstream of it but translation can only be initiated from the ATG of the cre gene downstream of the promoter, resulting in tissue specific expression of cre protein in cerebellar Purkinje cells. (NOTE: A GFP transgene co-integrated with the Tg(Pcp2-cre)1Amc transgene. As such, GFP expression is reported in the cerebellum [personal communication]) (J:92189, J:96313)
 Tissue activity of this recombinase allele
Driver: Pcp2     Summary of all recombinase alleles driven by Pcp2.

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Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Original:  J:92189 Lewis PM, et al., Sonic hedgehog signaling is required for expansion of granule neuron precursors and patterning of the mouse cerebellum. Dev Biol. 2004 Jun 15;270(2):393-410
All:  24 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.15
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