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Mavstm1Zjc
Targeted Allele Detail
Nomenclature
Symbol: Mavstm1Zjc
Name: mitochondrial antiviral signaling protein; targeted mutation 1, Zhijian J Chen
MGI ID: MGI:3654145
Synonyms: Mavs-
Gene: Mavs  Location: Chr2:131234063-131248025 bp, + strand  Genetic Position: Chr2, 63.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:110905
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsSequence beginning at the ATG in exon 2 and extending through exon 3 was replaced with a floxed neomycin resistance gene. Immunoblot failed to detect protein in mutants. (J:110905)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mavs Mutation:  25 strains or lines available
References
Original:  J:110905 Sun Q, et al., The specific and essential role of MAVS in antiviral innate immune responses. Immunity. 2006 May;24(5):633-42
All:  59 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
11/26/2019
MGI 6.14
The Jackson Laboratory