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Targeted Allele Detail
Symbol: Cd8b1tm1Litt
Name: CD8 antigen, beta chain 1; targeted mutation 1, Dan R Littman
MGI ID: MGI:3654103
Synonyms: CD8beta0, CD8betanull
Gene: Cd8b1  Location: Chr6:71322788-71337492 bp, + strand  Genetic Position: Chr6, 32.14 cM
Germline Transmission:  Earliest citation of germline transmission: J:112551
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exon 2 and part of intron 3 with a neomycin resistance gene. The result was a loss of 37% of the coding sequence, including most of the immunoglobulin-like domain and the entire J-like region. (J:112551)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Cd8b1 Mutation:  13 strains or lines available
Original:  J:112551 Crooks ME, et al., Disruption of T lymphocyte positive and negative selection in mice lacking the CD8 beta chain. Immunity. 1994 Jul;1(4):277-85
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
The Jackson Laboratory