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Slc6a3tm1Hhg
Targeted Allele Detail
Nomenclature
Symbol: Slc6a3tm1Hhg
Name: solute carrier family 6 (neurotransmitter transporter, dopamine), member 3; targeted mutation 1, Howard H Gu
MGI ID: MGI:3653596
Synonyms: DAT-CI
Gene: Slc6a3  Location: Chr13:73536747-73578672 bp, + strand  Genetic Position: Chr13, 40.1 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:111041
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Hypomorph, Inserted expressed sequence)
Mutation:    Insertion
 
Mutation detailsA loxP-flanked neo was inserted into intron 3 with the L104V, F105C, and A109V mutations. The neo was subsequently removed from the locus. (J:111041)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Expression
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Slc6a3 Mutation:  43 strains or lines available
References
Original:  J:111041 Chen R, et al., Abolished cocaine reward in mice with a cocaine-insensitive dopamine transporter. Proc Natl Acad Sci U S A. 2006 Jun 13;103(24):9333-8
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
06/12/2018
MGI 6.12
The Jackson Laboratory