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Targeted Allele Detail
Symbol: Als2tm1Hay
Name: alsin Rho guanine nucleotide exchange factor; targeted mutation 1, M R Hayden
MGI ID: MGI:3653518
Synonyms: Als2-
Gene: Als2  Location: Chr1:59162926-59237231 bp, - strand  Genetic Position: Chr1, 29.33 cM
Germline Transmission:  Earliest citation of germline transmission: J:111035
Parent Cell Line:  mEMS128 (ES Cell)
Strain of Origin:  129S1/SvImJ
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA promoter trap strategy was used to replace exons 3 and 4 with an SA-IRES-betageo-pA cassette. The resulting protein encoded from the locus would contain only the five N-terminal amino acids fused to lacZ-neo, thereby inactivating both the full-length and the proposed short form of amyotrophic lateral sclerosis 2 (juvenile) homolog. Absence of protein was confirmed by Western blot analysis of cortex, cerebellum and testis. (J:111035)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Als2 Mutation:  18 strains or lines available
Original:  J:111035 Devon RS, et al., Als2-deficient mice exhibit disturbances in endosome trafficking associated with motor behavioral abnormalities. Proc Natl Acad Sci U S A. 2006 Jun 20;103(25):9595-600
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.15
The Jackson Laboratory