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Fli1tm1Ber
Targeted Allele Detail
Nomenclature
Symbol: Fli1tm1Ber
Name: Friend leukemia integration 1; targeted mutation 1, Alan Bernstein
MGI ID: MGI:3652588
Synonyms: Fli-1-
Gene: Fli1  Location: Chr9:32422204-32542861 bp, - strand  Genetic Position: Chr9, 17.74 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:33052
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA neomycin resisitance gene replaced exon 2 such that the resulting frame shift mutation would disrupt all but the first 10 amino acids of the protein. Western blot confirmed absence of protein in mutant spleens. (J:33052)
Phenotypes
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Fli1 Mutation:  5 strains or lines available
References
Original:  J:33052 Melet F, et al., Generation of a novel Fli-1 protein by gene targeting leads to a defect in thymus development and a delay in Friend virus-induced erythroleukemia. Mol Cell Biol. 1996 Jun;16(6):2708-18
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/07/2015
MGI 5.21
The Jackson Laboratory