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Runx3tm2Yg
Targeted Allele Detail
Nomenclature
Symbol: Runx3tm2Yg
Name: runt related transcription factor 3; targeted mutation 2, Yoram Groner
MGI ID: MGI:3641439
Synonyms: Runx3VWRPY-
Gene: Runx3  Location: Chr4:135120652-135177990 bp, + strand  Genetic Position: Chr4, 67.19 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109584
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Nucleotide substitutions
 
Mutation detailsA targeting vector was designed such that the codons of the five C-terminal amino acids, VWRPY, were changed to the stop codon UAG and to codons encoding substituted amino acids designed to create a new NotI site. A loxP-flanked neo was included in intron 5 and was subsequently removed via cre-mediated excision. RT-PCR and Western blot analyses demonstrated expression of the mutant transcript and protein, respectively. (J:109584)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Runx3 Mutation:  7 strains or lines available
References
Original:  J:109584 Yarmus M, et al., Groucho/transducin-like Enhancer-of-split (TLE)-dependent and -independent transcriptional regulation by Runx3. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7384-9
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory