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Kmt2atm1Djab
Targeted Allele Detail
Summary
Symbol: Kmt2atm1Djab
Name: lysine (K)-specific methyltransferase 2A; targeted mutation 1, Malek Djabali
MGI ID: MGI:3641250
Synonyms: deltaSET, MlldeltaSET-
Gene: Kmt2a  Location: Chr9:44714652-44792594 bp, - strand  Genetic Position: Chr9, 24.84 cM
Alliance: Kmt2atm1Djab page
Skeletal abnormalities in Kmt2atm1Djab/Kmt2atm1Djab mice

Show the 1 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109102
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe SET domain was replaced with a floxed neomycin resistance gene. A stop codon was introduced in frame to allow termination of protein synthesis in the absence of the SET domain. RT-PCR demonstrated that mutant transcript was expressed at the same levels as wild-type transcripts. (J:109102)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 4 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Kmt2a Mutation:  135 strains or lines available
References
Original:  J:109102 Terranova R, et al., Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6629-34
All:  3 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/12/2024
MGI 6.23
The Jackson Laboratory