Kmt2atm1Djab
Targeted Allele Detail
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Symbol: |
Kmt2atm1Djab |
Name: |
lysine (K)-specific methyltransferase 2A; targeted mutation 1, Malek Djabali |
MGI ID: |
MGI:3641250 |
Synonyms: |
deltaSET, MlldeltaSET- |
Gene: |
Kmt2a Location: Chr9:44714652-44792594 bp, - strand Genetic Position: Chr9, 24.84 cM
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Alliance: |
Kmt2atm1Djab page
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Skeletal abnormalities in Kmt2atm1Djab/Kmt2atm1Djab mice
Show the 1 phenotype image(s) involving this allele.
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Germline Transmission: |
Earliest citation of germline transmission:
J:109102
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Parent Cell Line: |
Not Specified (ES Cell)
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Strain of Origin: |
129P2/OlaHsd
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Allele Type: |
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Targeted (Null/knockout) |
Mutations: |
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Insertion, Intragenic deletion
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Mutation details: The SET domain was replaced with a floxed neomycin resistance gene. A stop codon was introduced in frame to allow termination of protein synthesis in the absence of the SET domain. RT-PCR demonstrated that mutant transcript was expressed at the same levels as wild-type transcripts.
(J:109102)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Kmt2a Mutation: |
135 strains or lines available
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Original: |
J:109102 Terranova R, et al., Histone and DNA methylation defects at Hox genes in mice expressing a SET domain-truncated form of Mll. Proc Natl Acad Sci U S A. 2006 Apr 25;103(17):6629-34 |
All: |
3 reference(s) |
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