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Tg(Tyr-cre/ERT2)13Bos
Transgene Detail
Nomenclature
Symbol: Tg(Tyr-cre/ERT2)13Bos
Name: transgene insertion 13, Marcus Bosenberg
MGI ID: MGI:3641203
Synonyms: Tyr::CreER, Tyr::CreERT2, Tyr::CreERT2-Bos
Transgene: Tg(Tyr-cre/ERT2)13Bos  Location: unknown  
Transgene
origin
Strain of Origin:  FVB
Transgene
description
Transgene Type:    Transgenic (Inducible, Recombinase)
Inducer:    tamoxifen
Mutations:    Insertion, Intergenic deletion
 
Mutation detailsThis transgene consists of a 5.5 kb fragment of the Tyr promoter and a 3.6 kb fragment of the Tyr enhancer driving expression of a tamoxifen inducible form of cre recombinase. 3 lines were generated which all showed tamoxifen-inducible Cre activity in cutaneous melanocytes. This is a representative record for all 3 lines. Line 13 contains 2 copies of the transgene inserted into chromosome 2 (chr2:129,989,606; NCBI37/mm9) 7.8 kb downstream of Snrpb and 9.6 kb downstream of Tgm6 with a 3 kb deletion at the integration site. In addition three or more copies of the transgene integrated on chromosome 2 and resulted in ~3 kb deletion of this intergenic region between base pairs 130,160,936 and 130,163,877 [mouse mm10]. (J:110143, J:240920, J:282623)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Tyr     Summary of all recombinase alleles driven by Tyr.
 

Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 4 strains available      Cell Lines: 0 lines available
References
Original:  J:110143 Bosenberg M, et al., Characterization of melanocyte-specific inducible Cre recombinase transgenic mice. Genesis. 2006 May;44(5):262-7
All:  91 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
01/21/2020
MGI 6.14
The Jackson Laboratory