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Targeted Allele Detail
Symbol: Dicer1tm1Smr
Name: dicer 1, ribonuclease type III; targeted mutation 1, Sarah E Millar
MGI ID: MGI:3641051
Synonyms: DicerflEx22-23, Dicerflox
Gene: Dicer1  Location: Chr12:104687742-104751952 bp, - strand  Genetic Position: Chr12, 54.83 cM, cytoband E-F1
Dilated cardiomyopathy in Dicer1tm1Smr/Dicer1tm1Smr Tg(Myh6-cre)2182Mds/0 hearts

Show the 2 phenotype image(s) involving this allele.

Germline Transmission:  Earliest citation of germline transmission: J:110268
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Allele Type:    Targeted (Conditional ready, No functional change)
Mutation:    Insertion
Mutation detailsA floxed Dicer1 allele was created in a stem cell line (4E4) which contained a null Dicer1 allele, Dicer1tm1Ghan. A Dicer1 allele with exons 22 and 23 flanked by loxP sites replaced the remaining wild-type Dicer1 allele in the ES cells. The resulting ES cells were used to create conditional mice homozygous for the floxed Dicer1 allele. (J:101186)
Generation of the Dicer1tm1Smr allele
View phenotypes and curated references for all genotypes (concatenated display).
Disease models
In Mice Carrying this Mutation: 20 assay results
In Structures Affected by this Mutation: 24 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Dicer1 Mutation:  21 strains or lines available
Phenotypic Similarity to Human Syndrome: Glomerulocystic Disease J:229188.
Original:  J:110268 Andl T, et al., The miRNA-processing enzyme dicer is essential for the morphogenesis and maintenance of hair follicles. Curr Biol. 2006 May 23;16(10):1041-9
All:  43 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.16
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