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Targeted Allele Detail
Symbol: Gucy1a1tm1.1Dko
Name: guanylate cyclase 1, soluble, alpha 1; targeted mutation 1.1, Doris Koesling
MGI ID: MGI:3640804
Synonyms: alpha1-KO
Gene: Gucy1a1  Location: Chr3:82092427-82145789 bp, - strand  Genetic Position: Chr3, 35.97 cM
Germline Transmission:  Earliest citation of germline transmission: J:110362
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutation:    Intragenic deletion
Mutation detailsExon 4 was flanked with a loxP flanked neo cassette and a single loxP site via homologous recombination. Cre mediated recombination then removed exon 4. Western blot analysis confirmed the absence of protein expression in homozygous brain and lungs. (J:110362)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gucy1a1 Mutation:  22 strains or lines available
Original:  J:110362 Mergia E, et al., Spare guanylyl cyclase NO receptors ensure high NO sensitivity in the vascular system. J Clin Invest. 2006 Jun;116(6):1731-7
All:  8 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.12
The Jackson Laboratory