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Tg(Pomc1-cre)16Lowl
Transgene Detail
Nomenclature
Symbol: Tg(Pomc1-cre)16Lowl
Name: transgene insertion 16, Bradford B Lowell
MGI ID: MGI:3640616
Synonyms: Pomc-Cre, Tg(Pomc1-cre)1Lowl
Transgene: Tg(Pomc1-cre)16Lowl  Location: unknown  
Transgene
origin
Strain of Origin:  FVB/N
Transgene
description
Transgene Type:    Transgenic (Recombinase)
Mutation:    Insertion
 
Mutation detailsThis transgene consists of a Pomc1 BAC such that cre is driven by Pomc1 regulatory elements. Cre is expressed in POMC neurons in the arcuate nucleus of the hypothalamus and scattered cre activity is also seen in the dentate gyrus of the hippocampus. (J:106354)
Recombinase
activity
Activity:
 Tissue activity of this recombinase allele
Driver: Pomc     Summary of all recombinase alleles driven by Pomc.
 

Phenotypes
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View phenotypes for all genotypes (concatenated display).
Disease models
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Expression
In Mice Carrying this Mutation: 1 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
References
Original:  J:106354 Balthasar N, et al., Leptin receptor signaling in POMC neurons is required for normal body weight homeostasis. Neuron. 2004 Jun 24;42(6):983-91
All:  64 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/21/2015
MGI 5.21
The Jackson Laboratory