Otoftm1Ugds
Targeted Allele Detail
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Symbol: |
Otoftm1Ugds |
Name: |
otoferlin; targeted mutation 1, Unite de Genetique des Deficits Sensoriels |
MGI ID: |
MGI:3640614 |
Synonyms: |
Otof- |
Gene: |
Otof Location: Chr5:30524406-30619276 bp, - strand Genetic Position: Chr5, 16.48 cM, cytoband B1
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Alliance: |
Otoftm1Ugds page
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Germline Transmission: |
Earliest citation of germline transmission:
J:116097
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Parent Cell Line: |
CK35 (ES Cell)
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Strain of Origin: |
129S2/SvPas
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Allele Type: |
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Targeted (Null/knockout) |
Mutation: |
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Intragenic deletion
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Mutation details: Exons 14 and 15, encoding most of the C2C domain of the protein, have been deleted. RT-PCR analysis of cochleae of homozygous mutant mice confirmed the presence of an mRNA lacking the sequence encoded by the deleted exons. Translation of this mRNA would be frame-shifted, leading to a premature termination codon; absence of the expected truncated protein in homozygous mutant cochleae was demonstrated by immunohistolabeling and immunoblot analysis.
(J:116097)
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Inheritance: |
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Recessive |
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Otof Mutation: |
108 strains or lines available
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Original: |
J:116097 Roux I, et al., Otoferlin, defective in a human deafness form, is essential for exocytosis at the auditory ribbon synapse. Cell. 2006 Oct 20;127(2):277-89 |
All: |
13 reference(s) |
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