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Myctm1.1Dmlo
Targeted Allele Detail
Summary
Symbol: Myctm1.1Dmlo
Name: myelocytomatosis oncogene; targeted mutation 1.1, Dominique Morello
MGI ID: MGI:3640383
Synonyms: Delta3'SV
Gene: Myc  Location: Chr15:61857240-61862223 bp, + strand  Genetic Position: Chr15, 26.19 cM, cytoband D2-D3
Alliance: Myctm1.1Dmlo page
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:70610
Parent Cell Line:  CK35 (ES Cell)
Strain of Origin:  129S2/SvPas
Mutation
description
Allele Type:    Targeted (Humanized sequence)
Mutation:    Insertion
 
Mutation detailsMice carrying the Myctm1Dmlo allele were crossed with mice expressing cre recombinase, resulting in the loss of the floxed neo while the human MYC carboxy terminal remained in place of the endogenous sequence and the 3'UTR was replaced by late SV40 3' UTR. (J:70610)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myc Mutation:  42 strains or lines available
References
Original:  J:70610 Langa F, et al., Healthy mice with an altered c-myc gene: role of the 3' untranslated region revisited. Oncogene. 2001 Jul 19;20(32):4344-53
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory