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Hmgcltm1Gam
Targeted Allele Detail
Nomenclature
Symbol: Hmgcltm1Gam
Name: 3-hydroxy-3-methylglutaryl-Coenzyme A lyase; targeted mutation 1, Grant A Mitchell
MGI ID: MGI:3640351
Synonyms: HL-
Gene: Hmgcl  Location: Chr4:135946448-135962617 bp, + strand  Genetic Position: Chr4, 68.14 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52117
Parent Cell Line:  CGR8 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
    Exon 2 was replaced by a neomycin resistance gene. (J:52117)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hmgcl Mutation:  4 strains or lines available
References
Original:  J:52117 Wang SP, et al., 3-Hydroxy-3-methylglutaryl-CoA lyase (HL): gene targeting causes prenatal lethality in HL-deficient mice. Hum Mol Genet. 1998 Dec;7(13):2057-62
All:  1 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
04/18/2017
MGI 6.08
The Jackson Laboratory