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Targeted Allele Detail
Symbol: Cpt1ctm1Mdln
Name: carnitine palmitoyltransferase 1c; targeted mutation 1, M Daniel Lane
MGI ID: MGI:3639356
Gene: Cpt1c  Location: Chr7:44959372-44974851 bp, - strand  Genetic Position: Chr7, 29.07 cM, cytoband B2
Germline Transmission:  Earliest citation of germline transmission: J:109455
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
Mutation detailsA targeting vector was designed to replace exons 1 and 2, encoding the transcription initiation site and the first transmembrane domain of the protein, with a neomycin resistance cassette. Western blot failed to detect protein in mutant brains. (J:109455)
View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cpt1c Mutation:  29 strains or lines available
Original:  J:109455 Wolfgang MJ, et al., The brain-specific carnitine palmitoyltransferase-1c regulates energy homeostasis. Proc Natl Acad Sci U S A. 2006 May 9;103(19):7282-7
All:  2 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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MGI 6.11
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