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Hpntm1Qwu
Targeted Allele Detail
Nomenclature
Symbol: Hpntm1Qwu
Name: hepsin; targeted mutation 1, Qingyu Wu
MGI ID: MGI:3639336
Synonyms: Tmprss1-
Gene: Hpn  Location: Chr7:31098725-31115290 bp, - strand  Genetic Position: Chr7, 19.3 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:45393
Parent Cell Line:  RW-4 (ES Cell)
Strain of Origin:  129X1/SvJ
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsExons 5-8, which encode the conserved activation site and most of the catalytic domain, were deleted and replaced with a neomycin selection cassette. Northern blot analysis of total liver RNA derived from mutant mice demonstrated that no detectable transcript is expressed from this allele. (J:45393)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hpn Mutation:  13 strains or lines available
References
Original:  J:45393 Wu Q, et al., Generation and characterization of mice deficient in hepsin, a hepatic transmembrane serine protease. J Clin Invest. 1998 Jan 15;101(2):321-6
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
10/10/2017
MGI 6.10
The Jackson Laboratory