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Msntm1Sts
Targeted Allele Detail
Nomenclature
Symbol: Msntm1Sts
Name: moesin; targeted mutation 1, Shoichiro Tsukita
MGI ID: MGI:3630284
Gene: Msn  Location: ChrX:96096042-96168552 bp, + strand  Genetic Position: ChrX, 42.65 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:52936
Parent Cell Line:  J1 (ES Cell)
Strain of Origin:  129S4/SvJae
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsThe 3'end of exon 3 and part of intron 3 was replaced with a loxP-flanked neomycin selection cassette. A splice acceptor (SA) and polyadenylation signal (PA) were also placed at the 3' end of the cassette to minimize the possibility of producing aberrant transcripts that skip exon 3. Immunoblotting assays on mutant male ES cells (-/Y) demonstrated that no full length protein was expressed from this allele. (J:52936)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Msn Mutation:  16 strains or lines available
References
Original:  J:52936 Doi Y, et al., Normal development of mice and unimpaired cell adhesion/cell motility/actin-based cytoskeleton without compensatory up-regulation of ezrin or radixin in moesin gene knockout. J Biol Chem. 1999 Jan 22;274(4):2315-21
All:  6 reference(s)

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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/22/2016
MGI 6.06
The Jackson Laboratory