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Targeted Allele Detail
Symbol: Il2tm1Hua
Name: interleukin 2; targeted mutation 1, Hua Gu
MGI ID: MGI:3630259
Synonyms: Il-2-GFPki
Gene: Il2  Location: Chr3:37120713-37125954 bp, - strand  Genetic Position: Chr3, 18.3 cM, cytoband B-C
Germline Transmission:  Earliest citation of germline transmission: J:49411
Parent Cell Line:  E14.1 (ES Cell)
Strain of Origin:  129P2/OlaHsd
Allele Type:    Targeted (Null/knockout, Reporter)
Mutation:    Insertion
Mutation detailsA green fluorescent protein (GFP) cDNA was inserted into the first exon such that the endogenous promoter directs expression of GFP. An adjacent selectable marker was removed by cre-mediated recombination in ES cells prior to the production of chimeric mice. Expression of GFP was shown to mimic endogenous Il2 gene expression in both a temporal and spatial manner; induction experiments also showed that GFP expression was triggered by costimulatory signals similar to the endogenous gene. (J:49411)
View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Il2 Mutation:  28 strains or lines available
Original:  J:49411 Naramura M, et al., Mice with a fluorescent marker for interleukin 2 gene activation. Immunity. 1998 Aug;9(2):209-16
All:  7 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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MGI 6.14
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