Nfkbia^{tm1(Nfkbib)Brv}
Targeted Allele Detail

Summary

• Symbol: Nfkbia^{tm1(Nfkbib)Brv}
• Name: nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha; targeted mutation 1, Rodrigo Bravo
• MGI ID: MGI:3630257
• Synonyms: AKBI, IkappaBbeta KI
• Gene: Nfkbia Location: Chr12:55536195-55539432 bp, - strand Genetic Position: Chr12, 24.0 cM, cytoband C1-C3
• Alliance: Nfkbia^{tm1(Nfkbib)Brv} page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:50029
• Parent Cell Line: CJ7 (ES Cell)
• Strain of Origin: 129S1/Sv-Oca2⁺ Tyr⁺ Kitl⁺

Mutation description

• Allele Type: Targeted (Inserted expressed sequence, Null/knockout)
• Mutation: Insertion
• Mutation details: A cDNA encoding the Nfkbib gene with a bacterial phage T7 coding tag at the 5'end replaced the coding sequence of the Nfkbia gene. Immunoprecipitation and western blotting experiments demonstrated that the inserted sequence is expressed from the Nfkbia endogenous promoter. (J:50029)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Nfkbia Mutation: 19 strains or lines available

References

• Original: J:50029 Cheng JD, et al., Functional redundancy of the nuclear factor kappa B inhibitors I kappa B alpha and I kappa B beta. J Exp Med. 1998 Sep 21;188(6):1055-62
• All: 4 reference(s)