Akr1b7^tm1Fth
Targeted Allele Detail

Summary

• Symbol: Akr1b7^tm1Fth
• Name: aldo-keto reductase family 1, member B7; targeted mutation 1, Franz Theuring
• MGI ID: MGI:3629296
• Gene: Akr1b7 Location: Chr6:34389297-34400072 bp, + strand Genetic Position: Chr6, 14.95 cM
• Alliance: Akr1b7^tm1Fth page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:123295
• Parent Cell Line: E14.1 (ES Cell)
• Strain of Origin: 129P2/OlaHsd

Mutation description

• Allele Type: Targeted (Conditional ready, No functional change)
• Mutation: Insertion
• Mutation details: A lox P site was inserted 5' of exon 2 and a floxed PGK-neomycin selection cassette was inserted 3' of exon 4. Transient cre expression in these ES cells resulted in excision of the neomycin selection cassette and left exons 2, 3 and 4 flanked by loxP sites. (J:123295)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any Akr1b7 Mutation: 25 strains or lines available

References

• Original: J:123295 Baumann C, et al., AKR1B7 (mouse vas deferens protein) is dispensable for mouse development and reproductive success. Reproduction. 2007 Jul;134(1):97-109
• All: 1 reference(s)