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Xiaptm1Vdr
Targeted Allele Detail
Nomenclature
Symbol: Xiaptm1Vdr
Name: X-linked inhibitor of apoptosis; targeted mutation 1, J E Visvader
MGI ID: MGI:3629213
Synonyms: Xiap-
Gene: Xiap  Location: ChrX:42059679-42109656 bp, + strand  Genetic Position: ChrX, 23.19 cM, cytoband A3-A5
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109330
Parent Cell Line:  W9.5/W95 (ES Cell)
Strain of Origin:  129S1/Sv-Oca2+ Tyr+ Kitl+
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 1 and 2 with a neomycin resistance gene. The deleted sequence contains the initiation codon, the first two BIR domains and the third BIR domain. Western blot showed absence of protein in mutants. (J:109330)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xiap Mutation:  36 strains or lines available
References
Original:  J:109330 Olayioye MA, et al., XIAP-deficiency leads to delayed lobuloalveolar development in the mammary gland. Cell Death Differ. 2005 Jan;12(1):87-90
All:  9 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
12/05/2017
MGI 6.11
The Jackson Laboratory