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Sohlh1tm1Rajk
Targeted Allele Detail
Nomenclature
Symbol: Sohlh1tm1Rajk
Name: spermatogenesis and oogenesis specific basic helix-loop-helix 1; targeted mutation 1, Aleksandar Rajkovic
MGI ID: MGI:3629211
Synonyms: Sohlh1-
Gene: Sohlh1  Location: Chr2:25842995-25847248 bp, - strand  Genetic Position: Chr2, 18.21 cM
Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:109310
Parent Cell Line:  AB2.2 (ES Cell)
Strain of Origin:  129S7/SvEvBrd-Hprtb-m2
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA targeting vector was designed to replace exons 2-8 with a pgk-NPRT cassette. The deleted sequence included 500 nucleotides upstream of the putative transcriptional initiation site and the first three exons that encode the bHLH domain. Semi-quantitative RT-PCR confirmed absence of transcript in mutant testes. (J:109310)
Phenotypes
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View phenotypes for all genotypes (concatenated display).
Expression
In Mice Carrying this Mutation: 22 assay results
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Sohlh1 Mutation:  6 strains or lines available
References
Original:  J:109310 Ballow D, et al., Sohlh1 is essential for spermatogonial differentiation. Dev Biol. 2006 Jun 1;294(1):161-7
All:  4 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
08/23/2016
MGI 6.05
The Jackson Laboratory