Phf21a^tm1Tba
Targeted Allele Detail

Summary

• Symbol: Phf21a^tm1Tba
• Name: PHD finger protein 21A; targeted mutation 1, Tadashi Baba
• MGI ID: MGI:3629054
• Synonyms: Bhc80^-
• Gene: Phf21a Location: Chr2:92014451-92195011 bp, + strand Genetic Position: Chr2, 50.8 cM
• Alliance: Phf21a^tm1Tba page

Mutation origin

• Germline Transmission: Earliest citation of germline transmission: J:109077
• Parent Cell Line: D3 (ES Cell)
• Strain of Origin: 129S2/SvPas

Mutation description

• Allele Type: Targeted (Null/knockout)
• Mutations: Insertion, Intragenic deletion
• Mutation details: A targeting vector was designed to replace part of the seventh exon with a neomycin resistance cassette. The deleted sequence encoded a Gln-rich domain. RT-PCR and Western blot failed to detect transcript or protein, respectively, in mutants. (J:109077)

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 1 strain available Cell Lines: 0 lines available
• Carrying any Phf21a Mutation: 183 strains or lines available

References

• Original: J:109077 Iwase S, et al., A component of BRAF-HDAC complex, BHC80, is required for neonatal survival in mice. FEBS Lett. 2006 May 29;580(13):3129-35
• All: 1 reference(s)