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Targeted Allele Detail
Symbol: Kdrtm2.1Jrt
Name: kinase insert domain protein receptor; targeted mutation 2.1, Janet Rossant
MGI ID: MGI:3629041
Synonyms: Flk1-EGFP(neo out), Flk1-GFP, VEGFR2-GFP
Gene: Kdr  Location: Chr5:75932827-75978458 bp, - strand  Genetic Position: Chr5, 40.23 cM
Germline Transmission:  Earliest citation of germline transmission: J:109435
Parent Cell Line:  R1 (ES Cell)
Strain of Origin:  (129X1/SvJ x 129S1/Sv)F1-Kitl+
Allele Type:    Targeted (Null/knockout, Reporter)
Mutations:    Insertion, Intragenic deletion
Mutation detailsAn in-frame EGFP cDNA gene and a floxed PGK-neomycin resistance cassette replaced the translated portion of the first coding exon and the proximal part of the next intron, and placed EGFP under the transcriptional control of the endogenous promoter. The floxed PGK-neomycin promoter was subsequently removed by crossing to a cre-deleter strain. (J:109435)
View phenotypes and curated references for all genotypes (concatenated display).
In Structures Affected by this Mutation: 2 anatomical structures
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Kdr Mutation:  10 strains or lines available
Original:  J:109435 Ema M, et al., Deletion of the selection cassette, but not cis-acting elements, in targeted Flk1-lacZ allele reveals Flk1 expression in multipotent mesodermal progenitors. Blood. 2006 Jan 1;107(1):111-7
All:  27 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
MGI 6.14
The Jackson Laboratory